Title: Dexamethasone ester treatment alters insulin-like growth factor-I, its binding proteins and thyroid status in finishing calves
Authors: Bertozzi, C ×
Portetelle, D
Massart, S
Prandi, A
Darras, Veerle
Room, G
Tassinari, M
Vleurick, L
Parmentier, I
Haezebroeck, V
Decuypere, Eddy
Burny, A
Renaville, R #
Issue Date: Jun-2000
Publisher: Agr inst canada
Series Title: Canadian journal of animal science vol:80 issue:2 pages:329-335
Abstract: To improve carcass quality in finishing calves, some breeders use preparations containing corticoids alone or in association with other growth promoters. We have investigated the effects of dexamethasone treatment on insulin-like growth factor-I (IGF-I), IGF-binding proteins (IGFBP-2 and 3) and thyroid hormones (T-3, T-4, free T-4). Limousine male calves were allocated to a control group (C) (n = 18) and a group (n = 18) that received dexamethasone esters (DEX). Blood and hepatic tissue samples were collected at slaughtering. Thyroid hormones and IGF-I plasma levels were measured by RIA and IGFBPs were evaluated by immunoblotting. Hepatic type I 5'deiodinase (5'D-I) activity was determined by enzyme assay and hepatic expression of mRNA for GH receptor, IGF-I, IGFBP-2, IGFBP-3 and type I deiodinase (D-I) was evaluated by dot blot analysis. Plasma IGF-I and IGFBP-3 levels were reduced by the DEX treatment (P < 0.001 and P < 0.01, respectively) while IGFBP-2 was unaffected. Significant plasma changes for IGF-I and IGFBP-3 were not corroborated by hepatic mRNA levels, for which only a slight non-significant decrease was noted. Growth hormone receptor mRNA expression was increased after treatment (P < 0.01). T-3 plasma level was higher in DEX animals (P < 0.05) than in C calves. Finally, treatment increased 5'D-I activity in the hepatic tissue (P < 0.001) and seemed to also affect D-I mRNA expression (P = 0.1). In conclusion, dexamethasone ester injection in calves altered some of their endocrinological parameters; this could explain the catabolic action of corticoids in the bovine species.
ISSN: 0008-3984
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Animal Physiology and Neurobiology Section - miscellaneous
Division of Livestock-Nutrition-Quality (-)
× corresponding author
# (joint) last author

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