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Title: Pharmacology of stomoxytachykinin receptor depends on second messenger system
Authors: Poels, Jeroen ×
Nachman, RJ
Akerman, KE
Oonk, HB
Guerrero, F
De Loof, Arnold
Janecka, AE
Torfs, Herbert
Vanden Broeck, Jozef #
Issue Date: Jan-2005
Publisher: Elsevier science inc
Series Title: Peptides vol:26 issue:1 pages:109-114
Abstract: STKR is a neurokinin receptor derived from the stable fly, Stomoxys calcitrans. Insect tachykinin-related peptides, also referred to as "insectatachykinins", produce dose-dependent calcium and cyclic AMP responses in cultured Drosophila melanogaster Schneider 2 (S2) cells that were stably transfected with the cloned STKR cDNA. Pronounced differences in Pharmacology were observed between agonist-induced calcium and cyclic AMP responses. The results indicate that the pharmacological properties of STKR depend on its coupling to a unique second messenger system. Therefore, a model postulating the existence of multiple active receptor conformations is proposed. This article presents the first evidence that an insect peptide receptor with dual coupling properties to second messenger systems can display agonist-dependent functional differences. (C) 2004 Elsevier Inc. All rights reserved.
URI: 
ISSN: 0196-9781
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Animal Physiology and Neurobiology Section - miscellaneous
Department of Biology - miscellaneous
× corresponding author
# (joint) last author

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