Title: Folliculostatins, gonadotropins and a model for control of growth in the grey fleshfly, Neobellieria (Sarcophaga) bullata
Authors: De Loof, Arnold
Bylemans, Dany
Schoofs, Liliane
Janssen, Ine
Spittaels, K
Vanden Broeck, Jozef
Huybrechts, Roger
Borovsky, D
Hua, YJ
Koolman, J
Sower, S # ×
Issue Date: Jun-1995
Publisher: Pergamon Press
Series Title: Insect biochemistry and molecular biology vol:25 issue:6 pages:661-667
Abstract: The sequences of two folliculostatic peptides of the fleshfly Neobellieria bullata have been determined recently. The first peptide (Neb-TMOF: H-NPTNLH-OH), originates from a 75 kDa precursor protein found in vitellogenic oocytes. The hexapeptide directly inhibits the synthesis of trypsin-like enzymes in the gut, and thus lowers the concentration of yolk polypeptides in the hemolymph. It also inhibits the biosynthesis of ecdysone in the larval ring gland. Therefore, it could also be named prothoracicostatic hormone (Neb-PTSH). The second peptide (Neb-colloostatin: H-SIV-PLGLPVPIGPIVVGPR-OH) acts on previtellogenic follicles and is a cleaved product of a collagen-like precursor molecule. Our results indicate that peptides that are cleaved from matrix proteins could act as growth-inhibiting factors. Gonadotropin releasing hormone (GnRH)-immunolike peptides were not identified, but progress is being made in the isolation and characterization of factors which stimulate cAMP production by the ovary, Using these results, a novel model of growth control in which matrix proteins play an important role as a potential source of growth regulators has been developed.
ISSN: 0965-1748
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Animal Physiology and Neurobiology Section - miscellaneous
Division of Crop Biotechnics
Department of Biology - miscellaneous
× corresponding author
# (joint) last author

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