Title: From the genome to the proteome: Uncovering peptides in the Apis brain
Authors: Hummon, Amanda B
Richmond, Timothy
Verleyen, Peter
Baggerman, Geert
Huybrechts, Jurgen
Ewing, Michael A
Vierstraete, Evy
Rodriguez-Zas, Sandra L
Schoofs, Liliane
Robinson, Gene E
Sweedler, Jonathan V # ×
Issue Date: Oct-2006
Publisher: American Association for the Advancement of Science
Series Title: Science vol:314 issue:5799 pages:647-649
Abstract: Neuropeptides, critical brain peptides that modulate animal behavior by affecting the activity of almost every neuronal circuit, are inherently difficult to predict directly from a nascent genome sequence because of extensive posttranslational processing. The combination of bioinformatics and proteomics allows unprecedented neuropeptide discovery from an unannotated genome. Within the Apis mellifera genome, we have inferred more than 200 neuropeptides and have confirmed the sequences of 100 peptides. This study lays the groundwork for future molecular studies of Apis neuropeptides with the identification of 36 genes, 33 of which were previously unreported.
ISSN: 0036-8075
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Animal Physiology and Neurobiology Section - miscellaneous
Microbial and Molecular Systems - miscellaneous
× corresponding author
# (joint) last author

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