Title: Inhibition of ecdysone biosynthesis in flies by a hexapeptide isolated from vitellogenic ovaries
Authors: Hua, Yj ×
Bylemans, Dany
De Loof, Arnold
Koolman, J #
Issue Date: Aug-1994
Publisher: Elsevier sci ireland ltd
Series Title: Molecular and cellular endocrinology vol:104 issue:1 pages:R1-R4
Abstract: The only identified insect peptides known to be involved in controlling the biosynthesis of ecdysone, the steroid moulting hormone of arthropods, are the prothoracicotropic hormones (PTTH). These neuropeptides stimulate ecdysone biosynthesis. Recently, a hexapeptide (NPTNLH) with folliculostatic and trypsin modulating activity was isolated from vitellogenic ovaries of the fleshfly Neobellieria bullata. Here we report that the hexapeptide, when tested in vitro on the isolated ring gland of flies, inhibited ecdysone biosynthesis immediately and completely (EC(50) = 5 nM). The hexapeptide is the first known factor with 'prothoracicostatic activity' and may form part of the endocrine system that controls ecdysone biosynthesis in vivo.
ISSN: 0303-7207
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Division of Crop Biotechnics
Department of Biology - miscellaneous
× corresponding author
# (joint) last author

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