Title: Identification of 1-lysophosphatidylethanolamine (C-16:1) as an antimicrobial compound in the housefly, Musca domestica
Authors: Meylaers, K
Clynen, Elke
Daloze, D
De Loof, Arnold
Schoofs, Liliane # ×
Issue Date: Jan-2004
Publisher: Pergamon Press
Series Title: Insect biochemistry and molecular biology vol:34 issue:1 pages:43-49
Abstract: We observed that a methanolic whole body extract of uninfected last instar larvae of the housefly, Musca domestica, displayed antifungal and antibacterial activity. We have further purified this extract to a single active fraction using reversed phase high performance liquid chromatography. The pure fraction inhibited growth of the Gram-positive bacteria Bacillus thuringiensis and the yeast Saccharomyces cerevisiae, but not the Gram-negative bacteria Escherichia coli. The active compound was determined to have a molecular mass of 451.2 Da. Further analysis by nuclear magnetic resonance identified the substance as mono-unsaturated 1-lysophosphatidylethanolamine (C-16:1) (1-LPE). The structurally different and more common 2-LPE have been described as mediators of the antimicrobial activity of rimenophenazine antibiotic agents (Van Rensburg et al., 1992). Our results suggest that the isolated 1-LPE displays a higher activity in comparison, possibly based on structure-specific differences in activity. (C) 2003 Elsevier Ltd. All rights reserved.
ISSN: 0965-1748
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Animal Physiology and Neurobiology Section - miscellaneous
Department of Biology - miscellaneous
× corresponding author
# (joint) last author

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