Body mass index and breast cancer survival: a Mendelian randomization analysis

Guo, Qi; Burgess, Stephen; Turman, Constance; Bolla, Manjeet K; Wang, Qin; Lush, Michael; Abraham, Jean; Aittomäki, Kristiina; Andrulis, Irene L; Apicella, Carmel; Arndt, Volker; Phillips, Kelly-Anne; Poole, Christopher J; Pylkäs, Katri; Radice, Paolo; Rahman, Nazneen; Rüdiger, Thomas; Rudolph, Anja; Sawyer, Elinor J; Schumacher, Fredrick; Seibold, Petra; Barrdahl, Myrto; Seynaeve, Caroline; Shah, Mitul; Smeets, Ann; Southey, Melissa C; Tollenaar, Rob AEM; Tomlinson, Ian; Tsimiklis, Helen; Ulmer, Hans-Ulrich; Vachon, Celine; van den Ouweland, Ans MW; Benitez, Javier; Van't Veer, Laura J; Wildiers, Hans; Willett, Walter; Winqvist, Robert; Zamora, M Pilar; Chenevix-Trench, Georgia; Dörk, Thilo; Easton, Douglas F; García-Closas, Montserrat; Kraft, Peter; Berg, Christine D; Hopper, John L; Zheng, Wei; Schmidt, Marjanka K; Pharoah, Paul DP; Blomqvist, Carl; Bojesen, Stig E; Bonanni, Bernardo; Brand, Judith S; Brenner, Hermann; Broeks, Annegien; Burwinkel, Barbara; Caldas, Carlos; Campa, Daniele; Canzian, Federico; Chang-Claude, Jenny; Chanock, Stephen J; Chin, Suet-Feung; Couch, Fergus J; Cox, Angela; Cross, Simon S; Cybulski, Cezary; Czene, Kamila; Darabi, Hatef; Devilee, Peter; Diver, W Ryan; Dunning, Alison M; Earl, Helena M; Eccles, Diana M; Ekici, Arif B; Eriksson, Mikael; Evans, D Gareth; Fasching, Peter A; Figueroa, Jonine; Flesch-Janys, Dieter; Flyger, Henrik; Gapstur, Susan M; Gaudet, Mia M; Giles, Graham G; Glendon, Gord; Grip, Mervi; Gronwald, Jacek; Haeberle, Lothar; Haiman, Christopher A; Hall, Per; Hamann, Ute; Hankinson, Susan; Hartikainen, Jaana M; Hein, Alexander; Hiller, Louise; Hogervorst, Frans B; Holleczek, Bernd; Hooning, Maartje J; Hoover, Robert N; Humphreys, Keith; Hunter, David J; Hüsing, Anika; Jakubowska, Anna; Jukkola-Vuorinen, Arja; Kaaks, Rudolf; Kabisch, Maria; Kataja, Vesa; Knight, Julia A; Koppert, Linetta B; Kosma, Veli-Matti; Kristensen, Vessela N; Lambrechts, Diether; Le Marchand, Loic; Li, Jingmei; Lindblom, Annika; Lindström, Sara; Lissowska, Jolanta; Lubinski, Jan; Machiela, Mitchell J; Mannermaa, Arto; Manoukian, Siranoush; Margolin, Sara; Marme, Federik; Martens, John WM; McLean, Catriona; Menéndez, Primitiva; Milne, Roger L; Marie Mulligan, Anna; Muranen, Taru A; Nevanlinna, Heli; Neven, Patrick; Nielsen, Sune F; Nordestgaard, Børge G; Olson, Janet E; Perez, Jose IA; Peterlongo, Paolo

doi:10.1093/ije/dyx131

Body mass index and breast cancer survival: a Mendelian randomization analysis

Author:

Guo, Qi

Burgess, Stephen ; Turman, Constance ; Bolla, Manjeet K ; Wang, Qin ; Lush, Michael ; Abraham, Jean ; Aittomäki, Kristiina ; Andrulis, Irene L ; Apicella, Carmel ; Arndt, Volker ; Phillips, Kelly-Anne ; Poole, Christopher J ; Pylkäs, Katri ; Radice, Paolo ; Rahman, Nazneen ; Rüdiger, Thomas ; Rudolph, Anja ; Sawyer, Elinor J ; Schumacher, Fredrick ; Seibold, Petra ; Barrdahl, Myrto ; Seynaeve, Caroline ; Shah, Mitul ; Smeets, Ann ; Southey, Melissa C ; Tollenaar, Rob AEM ; Tomlinson, Ian ; Tsimiklis, Helen ; Ulmer, Hans-Ulrich ; Vachon, Celine ; van den Ouweland, Ans MW ; Benitez, Javier ; Van't Veer, Laura J ; Wildiers, Hans ; Willett, Walter ; Winqvist, Robert ; Zamora, M Pilar ; Chenevix-Trench, Georgia ; Dörk, Thilo ; Easton, Douglas F ; García-Closas, Montserrat ; Kraft, Peter ; Berg, Christine D ; Hopper, John L ; Zheng, Wei ; Schmidt, Marjanka K ; Pharoah, Paul DP ; Blomqvist, Carl ; Bojesen, Stig E ; Bonanni, Bernardo ; Brand, Judith S ; Brenner, Hermann ; Broeks, Annegien ; Burwinkel, Barbara ; Caldas, Carlos ; Campa, Daniele ; Canzian, Federico ; Chang-Claude, Jenny ; Chanock, Stephen J ; Chin, Suet-Feung ; Couch, Fergus J ; Cox, Angela ; Cross, Simon S ; Cybulski, Cezary ; Czene, Kamila ; Darabi, Hatef ; Devilee, Peter ; Diver, W Ryan ; Dunning, Alison M ; Earl, Helena M ; Eccles, Diana M ; Ekici, Arif B ; Eriksson, Mikael ; Evans, D Gareth ; Fasching, Peter A ; Figueroa, Jonine ; Flesch-Janys, Dieter ; Flyger, Henrik ; Gapstur, Susan M ; Gaudet, Mia M ; Giles, Graham G ; Glendon, Gord ; Grip, Mervi ; Gronwald, Jacek ; Haeberle, Lothar ; Haiman, Christopher A ; Hall, Per ; Hamann, Ute ; Hankinson, Susan ; Hartikainen, Jaana M ; Hein, Alexander ; Hiller, Louise ; Hogervorst, Frans B ; Holleczek, Bernd ; Hooning, Maartje J ; Hoover, Robert N ; Humphreys, Keith ; Hunter, David J ; Hüsing, Anika ; Jakubowska, Anna ; Jukkola-Vuorinen, Arja ; Kaaks, Rudolf ; Kabisch, Maria ; Kataja, Vesa ; Knight, Julia A ; Koppert, Linetta B ; Kosma, Veli-Matti ; Kristensen, Vessela N ; Lambrechts, Diether ; Le Marchand, Loic ; Li, Jingmei ; Lindblom, Annika ; Lindström, Sara ; Lissowska, Jolanta ; Lubinski, Jan ; Machiela, Mitchell J ; Mannermaa, Arto ; Manoukian, Siranoush ; Margolin, Sara ; Marme, Federik ; Martens, John WM ; McLean, Catriona ; Menéndez, Primitiva ; Milne, Roger L ; Marie Mulligan, Anna ; Muranen, Taru A ; Nevanlinna, Heli ; Neven, Patrick ; Nielsen, Sune F ; Nordestgaard, Børge G ; Olson, Janet E ; Perez, Jose IA ; Peterlongo, Paolo

Keywords:

Science & Technology, Life Sciences & Biomedicine, Public, Environmental & Occupational Health, Body mass index, breast cancer survival, Mendelian randomization, epidemiology, genetics, OBESITY, WOMEN, DIAGNOSIS, DISEASE, EPIDEMIOLOGY, METAANALYSIS, INSTRUMENTS, REGRESSION, PROGNOSIS, TRIAL, Body Mass Index, Breast Neoplasms, Causality, Europe, Female, Genetic Variation, Humans, Mendelian Randomization Analysis, Meta-Analysis as Topic, Polymorphism, Single Nucleotide, Receptors, Estrogen, Risk Assessment, Risk Factors, Survival Analysis, White People, kConFab/AOCS Investigators, 0104 Statistics, 1117 Public Health and Health Services, Epidemiology, 4202 Epidemiology, 4206 Public health, 4905 Statistics

Abstract:

There is increasing evidence that elevated body mass index (BMI) is associated with reduced survival for women with breast cancer. However, the underlying reasons remain unclear. We conducted a Mendelian randomization analysis to investigate a possible causal role of BMI in survival from breast cancer.