Title: Methylation Related to Perceived Parenting in Adolescents and Its Association to Depressive Symptoms Two Years Later
Authors: Van Assche, Evelien
Vangeel, Elise
Freson, Kathleen
Van Leeuwen, Karla
Verschueren, Karine
Colpin, Hilde
Van Den Noortgate, Wim
Goossens, Luc
Claes, Stephan
Issue Date: 4-Apr-2017
Conference: EPA edition:25 location:Florence date:1-4 April 2017
Abstract: Introduction: Adolescents’ wellbeing is affected by their parenting situation and can influence their wellbeing over time. We present an exploratory study with an Illumina 450k array, comparing methylation in adolescents, based on perceived parenting at T0, and how methylation can interact with parenting in explaining depressive symptoms two years later (T2).
Objectives: Identify differentially methylated regions (DMRs) associated with perceived parenting at T0 and investigate their association with depressive symptoms two years later.
Aims: An exploratory analysis evaluating the association between methylation and depressive symptoms longitudinally.
Methods: From two extreme parenting clusters: perceived supportive, and punishing-neglecting, we randomly selected 44 adolescents (MAge=14 at T0; 48%boys). The CES-D scale (Centre for Epidemiologic Studies Depression Scale) assessed depressive symptoms. DMRs were identified based on the parenting clusters (DMRcate and comb-p) using llumina Infinium HumanMethylation450 BeadChip data. Associations between the most significant CpG for each DMR and the depression score at T2, were calculated using linear regression analysis.
Results: We identified 17 DMRs, but only cg13306335 in PEX10 was associated with depressive symptoms at T2(p=.0014, Bonferroni(17 tests): p<.0029). Additionally, an interaction between parenting at T0 and PEX10 methylation (T0) in explaining depressive symptoms (T2) can be suggested (p=.014).
Conclusions: We show that methylation at PEX10’s most significant CpG is correlated with depressive symptoms at T2, these exploratory results also suggest a possible interaction between parenting and PEX10 methylation at T0 in association with depressive symptoms at T2. Validation in a larger sample is needed to support the role of methylation and its interactions in depression over time.
Publication status: published
KU Leuven publication type: IMa
Appears in Collections:Faculty of Psychology and Educational Sciences - miscellaneous
Faculty of Psychology and Educational Sciences, Campus Kulak Kortrijk – miscellaneous
School Psychology and Development in Context
Parenting and Special Education
Molecular and Vascular Biology
Research Group Psychiatry

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