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Title: Regulation of Drosophila Brain Wiring by Neuropil Interactions via a Slit-Robo-RPTP Signaling Complex
Authors: Oliva, Carlos ×
Soldano, Alessia
Mora, Natalia
De Geest, Natalie
Claeys, Annelies
Erfurth, Maria-Luise
Sierralta, Jimena
Ramaekers, Ariane
Dascenco, Dan
Ejsmont, Radoslaw Kamil
Schmucker, Dietmar
Sanchez-Soriano, Natalia
Hassan, Bassem A #
Issue Date: 2016
Publisher: Cell Press
Series Title: Developmental Cell vol:39 issue:2 pages:267-278
Article number: S1534-5807(16)30678-5
Abstract: The axonal wiring molecule Slit and its Round-About (Robo) receptors are conserved regulators of nerve cord patterning. Robo receptors also contribute to wiring brain circuits. Whether molecular mechanisms regulating these signals are modified to fit more complex brain wiring processes is unclear. We investigated the role of Slit and Robo receptors in wiring Drosophila higher-order brain circuits and identified differences in the cellular and molecular mechanisms of Robo/Slit function. First, we find that signaling by Robo receptors in the brain is regulated by the Receptor Protein Tyrosine Phosphatase RPTP69d. RPTP69d increases membrane availability of Robo3 without affecting its phosphorylation state. Second, we detect no midline localization of Slit during brain development. Instead, Slit is enriched in the mushroom body, a neuronal structure covering large areas of the brain. Thus, a divergent molecular mechanism regulates neuronal circuit wiring in the Drosophila brain, partly in response to signals from the mushroom body.
URI: 
ISSN: 1534-5807
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Neurogenetics (-)
Laboratory of Ion Channel Research (VIB-KU Leuven Center for Brain & Disease Research)
Neuronal Wiring Lab
× corresponding author
# (joint) last author

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