Title: Drosophila Pax-6/eyeless is essential for normal adult brain structure and function
Authors: Callaerts, Patrick ×
Leng, S
Clements, J
Benassayag, C
Cribbs, D
Kang, YY
Walldorf, U
Fischbach, KF
Strauss, R #
Issue Date: Feb-2001
Publisher: John wiley & sons inc
Series Title: Journal of neurobiology vol:46 issue:2 pages:73-88
Abstract: A role for the Pax-6 homologue eyeless in adult Drosophila brain development and function is described. eyeless expression is detected in neurons, but not glial cells, of the mushroom bodies, the medullar cortex, the lateral horn, and the pars intercerebralis. Furthermore, severe defects in adult brain structures essential for vision, olfaction, and for the coordination of locomotion are provoked by two newly isolated mutations of Pax-6/eyeless that result in truncated proteins. Consistent with the morphological lesions, we observe defective walking behavior for these eyeless mutants. The implications of these data for understanding postembryonic brain development and function in Drosophila are discussed. (C) 2001 John Wiley & Sons, Inc.
ISSN: 0022-3034
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Associated Laboratories - miscellaneous (-)
Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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