Morphological and anatomical features (including wood anatomy and pollen morphology) of the small neotropical genus Pagameopsis (Rubiaceae-Rubioideae) are discussed and illustrated. The fused ovaries, fenestrate corolla tube, basally attached anther filaments, and absence of raphides arc especially noteworthy. Pagameopsis is definitely not a member of the Psychotrieae because of significant differences in wood anatomy and gynoecial and fruit structure. A close affinity with Gaertnereae seems doubtful for similar reasons. The taxonomic affinities of Pagameopsis remain obscure. The genus shows similarities with several taxa of the Rubioideae, such as Coccocypseleae, Morindeae, Hedyotideae, and Metabolos. The absence of raphides, on the other hand, makes a position ill the Rubioideae doubtful.