Prevalence and clinical association of gene mutations through Multiplex Mutation Testing in patients with NSCLC: Results from the ETOP Lungscape Project

Kerr, KM; Dafni, U; Schulze, K; Thunnissen, E; Bubendorf, L; Hager, H; Finn, S; Biernat, W; Vliegen, L; Losa, JH; Marchetti, A; Cheney, R; Warth, A; Speel, E-J; Blackhall, F; Monkhorst, K; Jantus Lewintre, E; Tischler, V; Clark, C; Bertran-Alamillo, J; Meldgaard, P; Gately, K; Wrona, A; Vandenberghe, Peter; Felip, E; De Luca, G; Savic, S; Muley, T; Smit, EF; Dingemans, A-MC; Priest, L; Baas, P; Camps, C; Weder, W; Polydoropoulou, V; Geiger, TR; Kammler, R; Sumiyoshi, T; Molina, MA; Shames, DS; Stahel, RA; Peters, S

doi:10.1093/annonc/mdx629

Prevalence and clinical association of gene mutations through Multiplex Mutation Testing in patients with NSCLC: Results from the ETOP Lungscape Project

Author:

Kerr, KM

Dafni, U ; Schulze, K ; Thunnissen, E ; Bubendorf, L ; Hager, H ; Finn, S ; Biernat, W ; Vliegen, L ; Losa, JH ; Marchetti, A ; Cheney, R ; Warth, A ; Speel, E-J ; Blackhall, F ; Monkhorst, K ; Jantus Lewintre, E ; Tischler, V ; Clark, C ; Bertran-Alamillo, J ; Meldgaard, P ; Gately, K ; Wrona, A ; Vandenberghe, Peter ; Felip, E ; De Luca, G ; Savic, S ; Muley, T ; Smit, EF ; Dingemans, A-MC ; Priest, L ; Baas, P ; Camps, C ; Weder, W ; Polydoropoulou, V ; Geiger, TR ; Kammler, R ; Sumiyoshi, T ; Molina, MA ; Shames, DS ; Stahel, RA ; Peters, S

Keywords:

Science & Technology, Life Sciences & Biomedicine, Oncology, non-small-cell lung cancer, multiplex mutation analysis, EGFR, KRAS, PIK3CA, prognosis molecular staging, CELL LUNG-CANCER, TYROSINE KINASE INHIBITORS, PREDICT SURVIVAL, KRAS MUTATIONS, ADENOCARCINOMA, HETEROGENEITY, AMPLIFICATION, BRAF, Adult, Aged, Aged, 80 and over, Anaplastic Lymphoma Kinase, Carcinoma, Non-Small-Cell Lung, DNA Mutational Analysis, Female, Humans, Lung Neoplasms, Male, Middle Aged, Multiplex Polymerase Chain Reaction, Mutation, Neoplasm Staging, Prevalence, Progression-Free Survival, Proto-Oncogene Proteins c-met, Smoking, Young Adult, ETOP Lungscape Consortium, 1112 Oncology and Carcinogenesis, Oncology & Carcinogenesis, 3202 Clinical sciences, 3211 Oncology and carcinogenesis

Abstract:

Reported prevalence of driver gene mutations in non-small cell lung cancer (NSCLC) is highly variable and clinical correlations are emerging. Using NSCLC biomaterial and clinical data from the ETOP Lungscape iBiobank, we explore the epidemiology of mutations and association to clinicopathological features and patient outcome (relapse-free survival, time-to-relapse, overall survival).