ITEM METADATA RECORD
Title: Insulin-related peptides and their conserved signal transduction pathway
Authors: Claeys, Ilse ×
Simonet, Gert
Poels, Jeroen
Van Loy, Tom
Vercammen, Linda
De Loof, Arnold
Vanden Broeck, Jozef #
Issue Date: Apr-2002
Publisher: Elsevier science inc
Series Title: Peptides vol:23 issue:4 pages:807-816
Abstract: The 'insulin superfamily' is an ancient category of small, structurally related proteins, such as insulin, insulin-like growth factors (IGF) and relaxin. Insulin-like signaling molecules have also been described in different invertebrates, including nematodes, mollusks, and insects. They initiate an evolutionary conserved signal transduction mechanism by binding to a heterotetrameric, membrane-spanning receptor tyrosine kinase. Recent physiological and genetic studies have revealed that, in different metazoans, the insulin signaling pathway plays a pivotal role in the regulation of a variety of interrelated, fundamental processes, such as metabolism, growth, reproduction and aging. (C) 2002 Elsevier Science Inc. All rights reserved.
URI: 
ISSN: 0196-9781
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Animal Physiology and Neurobiology Section - miscellaneous
Department of Biology - miscellaneous
× corresponding author
# (joint) last author

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