Title: Sweet Substitute: A software tool for in silico fragmentation of peptide-linked N-glycans
Authors: Clerens, Stefan ×
Van den Ende, Wim
Verhaert, P
Geenen, L
Arckens, Lut #
Issue Date: Mar-2004
Publisher: Wiley-v c h verlag gmbh
Series Title: Proteomics vol:4 issue:3 pages:629-632
Abstract: A software tool, Sweet Substitute, is described, which assists tandem mass spectrometry (MS/MS)-based glycosylation characterization from within a tryptic digest. The algorithm creates a virtual nanoelectrospray-quadrupole time-of-flight style-MS/MS spectrum of any user-defined N-linked glycan structure. An empirical peak height modeling routine is implemented in the program. By comparing the theoretical MS/MS data with the deconvoluted and deisotoped experimental MS/MS data, the user is able to quickly assess whether a proposed candidate oligosaccharide structure is a plausible one.
ISSN: 1615-9853
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Animal Physiology and Neurobiology Section - miscellaneous
Molecular Physiology of Plants and Micro-organisms Section - miscellaneous
× corresponding author
# (joint) last author

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