Title: Immunocytochemical distribution of angiotensin-I converting enzyme in the central nervous system of insects and speculations about its possible function
Authors: Veelaert, Dirk
Schoofs, Liliane
Macours, Nathalie
Vandingenen, Anick
De Loof, Arnold
Isaac, E
Salzet, M
Huybrechts, Roger # ×
Issue Date: 1999
Publisher: Institute of Entomology, Czech Academy of Sciences
Series Title: European journal of entomology vol:96 issue:3 pages:323-326
Abstract: Insect peptidyl-dipeptidase A [angiotensin I - converting enzyme (ACE)] is a soluble single-domain peptidyl-dipeptidase that has many properties in common with the C-domain of mammalian somatic ACE and with the single-domain mammalian ACE. In agreement with a variety of insects, immunocytochemical studies reveal the presence of an ACE-like protein in Locusta migratoria. ACE-like immunoreactivity is present in neurosecretory cells of the pars intercerebralis. These cells have axons projecting into the nervus corporis cardiaci I and into the storage part of the corpus cardiacum, a neuroendocrine organ directly releasing into the aorta. The localisation of ACE in neurosecretory cells is consistent with its proposed role as a processing enzyme that is involved in the generation of active peptide hormones.
ISSN: 1210-5759
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Animal Physiology and Neurobiology Section - miscellaneous
Department of Biology - miscellaneous
× corresponding author
# (joint) last author

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