Title: Silica nanoparticles inhibit the cation channel TRPV4 in airway epithelial cells
Authors: Sanchez Linde, Alicia
Alvarez, Julio L
Demydenko, Kateryna
Jung, Carole
Aguiar Alpizar, Yeranddy
Alvarez Collazo, Julio
Cokic, Stevan
Valverde, Miguel A
Hoet, Peter
Talavera PĂ©rez, Karel # ×
Issue Date: Nov-2017
Publisher: BioMed Central
Series Title: Particle and Fibre Toxicology vol:14 issue:1 pages:43
Article number: 10.1186/s12989-017-0224-2
Abstract: Silica nanoparticles (SiNPs) have numerous beneficial properties and are extensively used in cosmetics and food industries as anti-caking, densifying and hydrophobic agents. However, the increasing exposure levels experienced by the general population and the ability of SiNPs to penetrate cells and tissues have raised concerns about possible toxic effects of this material. Although SiNPs are known to affect the function of the airway epithelium, the molecular targets of these particles remain largely unknown. Given that SiNPs interact with the plasma membrane of epithelial cells we hypothesized that they may affect the function of Transient Receptor Potential Vanilloid 4 (TRPV4), a cation-permeable channel that regulates epithelial barrier function. The main aims of this study were to evaluate the effects of SiNPs on the activation of TRPV4 and to determine whether these alter the positive modulatory action of this channel on the ciliary beat frequency in airway epithelial cells.
ISSN: 1743-8977
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Environment and Health - miscellaneous
Biomaterials - BIOMAT
Experimental Cardiology
Laboratory of Ion Channel Research (VIB-KU Leuven Center for Brain & Disease Research)
× corresponding author
# (joint) last author

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