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Title: Evidence for long-term sensitization of the bowel in patients with post-infectious-IBS
Authors: Balemans, Dafne ×
Mondelaers, S U
Cibert-Goton, V
Stakenborg, Nathalie
Aguilera-Lizarraga, J
Dooley, James
Liston, Adrian
Bulmer, D C
Vanden Berghe, Pieter
Boeckxstaens, Guy
Wouters, Mira #
Issue Date: Oct-2017
Publisher: Nature Publishing Group
Series Title: Scientific Reports vol:7 issue:1 pages:13606
Article number: 10.1038/s41598-017-12618-7
Abstract: Post-infectious irritable bowel syndrome (PI-IBS) is a common gastrointestinal disorder characterized by persistent abdominal pain despite recovery from acute gastroenteritis. The underlying mechanisms are unclear, although long-term changes in neuronal function, and low grade inflammation of the bowel have been hypothesized. We investigated the presence and mechanism of neuronal sensitization in a unique cohort of individuals who developed PI-IBS following exposure to contaminated drinking water 7 years ago. We provide direct evidence of ongoing sensitization of neuronal signaling in the bowel of patients with PI-IBS. These changes occur in the absence of any detectable tissue inflammation, and instead appear to be driven by pro-nociceptive changes in the gut micro-environment. This is evidenced by the activation of murine colonic afferents, and sensitization responses to capsaicin in dorsal root ganglia (DRGs) following application of supernatants generated from tissue biopsy of patients with PI-IBS. We demonstrate that neuronal signaling within the bowel of PI-IBS patients is sensitized 2 years after the initial infection has resolved. This sensitization appears to be mediated by a persistent pro-nociceptive change in the gut micro-environment, that has the capacity to stimulate visceral afferents and facilitate neuronal TRPV1 signaling.
URI: 
ISSN: 2045-2322
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Faculty of health and social work - UC Leuven
Laboratory of Genetics of Autoimmunity (VIB-KU Leuven Center for Brain & Disease Research)
Translational Research in GastroIntestinal Disorders
× corresponding author
# (joint) last author

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