Title: Characterization of tachykinin-related peptides from different insect species on Drosophila tachykinin receptor-expressing cell line
Authors: Fichna, Jakub ×
Poels, Jeroen
Vanden Broeck, Jozef
Janecka, Anna #
Issue Date: Nov-2006
Publisher: Blackwell publishing
Series Title: Chemical biology & drug design vol:68 issue:5 pages:284-286
Abstract: Drosophila tachykinin receptor, a neurokinin receptor cloned from the fruit fly Drosophila melanogaster, is a G-protein-coupled receptor, which upon activation by a peptide agonist induces a transient increase in the concentration of intracellular calcium. The functional assay based on aequorin-derived luminescence triggered by receptor-mediated changes in Ca2+ levels was used to examine and compare the effect of tachykinin-related peptides from different species. Among the endogenous Drosophila peptides, Drm-TK I induced the strongest calcium response. The most potent tachykinin-related peptides from Leucophaea maderae, Locusta migratoria, and Calliphora vomitoria, were partial agonists at the Drosophila tachykinin receptor.
ISSN: 1747-0277
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Animal Physiology and Neurobiology Section - miscellaneous
× corresponding author
# (joint) last author

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