Title: Cloning and tissue distribution of the chicken type 2 corticotropin-releasing hormone receptor
Authors: De Groef, Bert
Grommen, Sylvia
Mertens, Inge
Schoofs, Liliane
Kühn, Eduard
Darras, Veerle # ×
Issue Date: Aug-2004
Publisher: Academic Press
Series Title: General and Comparative Endocrinology vol:138 issue:1 pages:89-95
Abstract: We report the cloning of the complete coding sequence of the putative chicken type 2 corticotropin-releasing hormone receptor (CRH-R2) by rapid amplification of cDNA ends (RACE). The chicken CRH-R2 is a 412-amino acid 7-transmembrane G protein-coupled receptor, showing 87% identity to the Xenopus laevis and Oncorhynchus keta CRH-R2s, and 78-80% to mammalian CRH-R2s. The distribution of CRH-R2 mRNA was studied by RT-PCR analysis and compared to CRH-R1 distribution. Both CRH-R1 and CRH-R2 mRNA are expressed in the main chicken brain parts. In peripheral organs, CRH-R1 mRNA shows a more restricted distribution, whereas CRH-R2 mRNA is expressed in every tissue investigated, indicating that a number of actions of CRH and/or CRH-like peptides remain to be discovered in the chicken as well as in other vertebrates. (C) 2004 Elsevier Inc. All rights reserved.
ISSN: 0016-6480
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Animal Physiology and Neurobiology Section - miscellaneous
× corresponding author
# (joint) last author

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