Title: Identification of a glycogenolysis-inhibiting peptide from the corpora cardiaca of locusts
Authors: Clynen, Elke
Huybrechts, Jurgen
Baggerman, Geert
Van Doorn, J
Van der Horst, D
De Loof, Arnold
Schoofs, Liliane # ×
Issue Date: Aug-2003
Publisher: Association for the Study of Internal Secretions
Series Title: Endocrinology vol:144 issue:8 pages:3441-3448
Abstract: A mass spectrometric study of the peptidome of the neurohemal part of the corpora cardiaca of Locusta migratoria and Schistocerca gregaria shows that it contains several unknown peptides. We were able to identify the sequence of one of these peptides as pQSDLFLLSPK. This sequence is identical to the part of the Locusta insulin-related peptide (IRP) precursor that is situated between the signal peptide and the B-chain. We designated this peptide as IRP copeptide. This IRP copeptide is also present in the pars intercerebralis, which is likely to be the site of synthesis. It is identical in both L. migratoria and S. gregaria. It shows no effect on the hemolymph lipid concentration in vivo or muscle contraction in vitro. The IRP copeptide is able to cause a decreased phosphorylase activity in locust fat body in vitro, opposite to the effect of the adipokinetic hormones and therefore possibly represents a glycogenolysis-inhibiting peptide.
ISSN: 0013-7227
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Animal Physiology and Neurobiology Section - miscellaneous
Department of Biology - miscellaneous
Microbial and Molecular Systems - miscellaneous
× corresponding author
# (joint) last author

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