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Title: Postgenomic characterization of G-protein-coupled receptors
Authors: Mertens, Inge
Vandingenen, Anick
Meeusen, Tom
De Loof, Arnold
Schoofs, Liliane # ×
Issue Date: Sep-2004
Publisher: Ashley Publications
Series Title: Pharmacogenomics vol:5 issue:6 pages:657-672
Abstract: G-protein-coupled receptors (GPCRs) constitute one of the largest families of membrane-spanning proteins. Their importance in drug development has been proven over and over again. Therefore, they remain one of the most significant groups of molecules to be characterized. In the postgenomic era, the methods used for the characterization of GPCRs have dramatically changed: the predicted orphan receptors are now often used to ascertain the ligands (reverse pharmacology), whereas, in the past, the bioactive ligand was used to identify the receptor (classic approach). in this review, we will give an overview of the recent postgenomic functional assays that are frequently used to link the orphan GPCR of both vertebrate and invertebrate organisms with their ligands.
ISSN: 1462-2416
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Animal Physiology and Neurobiology Section - miscellaneous
Department of Biology - miscellaneous
× corresponding author
# (joint) last author

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