Title: Functional cross-reactivities of some locustamyotropins and Bombyx pheromone biosynthesis activating neuropeptide
Authors: Fonagy, A
Schoofs, Liliane
Matsumoto, S
De Loof, Arnold
Mitsui, T # ×
Issue Date: Sep-1992
Publisher: Pergamon Press
Series Title: Journal of Insect Physiology vol:38 issue:9 pages:651-657
Abstract: Naturally occurring, recently isolated insect neuropeptides locustamyotropin II and III and Bombyx pheromone biosynthesis activating neuropeptide I (PBAN-I) bearing common carboxy terminals (Phe-X-Pro-Arg-Leu-NH2) Were studied for possible functional cross-reactivities. On a Locusta oviduct and Leucophaea hindgut bioassay, synthetic Bombyx PBAN-I caused an increase in the spontaneous contractions at a threshold of 0.6 x 10(-8) and 1.45 +/- 0.4 x 10(-8) M, respectively. In Bombyx mori, injection of 0.001 pmol of locustamyotropin II and 0.01 pmol of locustamyotropin III/female induced bombykol production and maximal production was attained at 0.1 or 1 pmol dose, respectively. In Spodoptera litura pheromone production increased in a dose-dependent manner when 1-100 pmol of peptide was injected into females. When pheromone glands were incubated in vitro in Grace's medium containing different doses of locustamyotropin II or III, maximal sex pheromone production was induced at 5 pmol of peptide/150-mu-l medium in B. mori and at 15 pmol peptide/50-mu-l in S. litura, respectively. Present results support the idea that the common C-terminal pentapeptide (Phe-X-Pro-Arg-Leu-NH2) is responsible for both, myotropic and pheromonotropic activity.
ISSN: 0022-1910
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Animal Physiology and Neurobiology Section - miscellaneous
Department of Biology - miscellaneous
× corresponding author
# (joint) last author

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