Author:

Keywords:

pax6, squid, euprymna scolopes, eye, sensory organ, brain, development, gene, expression, drosophila, homeobox, segmentation, evolution, aniridia, eyeless, region, Science & Technology, Life Sciences & Biomedicine, Developmental Biology, Pax6, GENE, EXPRESSION, DROSOPHILA, HOMEOBOX, SEGMENTATION, EVOLUTION, ANIRIDIA, EYELESS, REGION, Amino Acid Sequence, Animals, Brain, Cell Nucleus, Cloning, Molecular, Decapodiformes, Embryo, Nonmammalian, Eye, Eye Proteins, Gene Expression Regulation, Developmental, Homeodomain Proteins, Molecular Sequence Data, PAX6 Transcription Factor, Paired Box Transcription Factors, Repressor Proteins, Sense Organs, Sequence Homology, Amino Acid, 06 Biological Sciences, 11 Medical and Health Sciences, 31 Biological sciences, 32 Biomedical and clinical sciences, 42 Health sciences

Abstract:

The cloning of a Pax6 orthologue from the sepiolid squid Euprymna scolopes and its developmental expression pattern are described. The data are consistent with the presence of a single gene encoding a protein with highly conserved DNA-binding paired and homeodomains. A detailed expression analysis by in situ hybridization and immunodetection revealed Pax6 mRNA and protein with predominantly nuclear localization in the developing eye, olfactory organ, brain lobes (optic lobe, olfactory lobe, peduncle lobe, superior frontal lobe and dorsal basal lobe), arms and mantle, suggestive of a role in eye, brain, and sensory organ development. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.