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Title: Neurotoxicity of polychlorinated biphenyls (PCBs) by disturbance of thyroid hormone-regulated genes
Authors: Roelens, SA ×
Beck, Veerle
Aerts, Goele
Clerens, Stefan
Van den Bergh, Gert
Arckens, Lut
Darras, Veerle
Van der Geyten, Serge #
Issue Date: Apr-2005
Publisher: New York Academy of Sciences
Series Title: Annals of the New York Academy of Sciences vol:1040 pages:454-456
Abstract: PCBs are known as neurotoxic compounds. Part of this neurotoxicity could be due to an alteration of the expression of TH-regulated genes in brain. To identify such genes, brain protein extracts of hypo- and hyperthyroid as well as PCB-treated embryos were compared by fluorescent 2D-DIGE. In total, we observed 109 differentially expressed proteins, of which 17 differed with both PCB and hypo- or hyperthyroid treatment. It was found that the interaction of PCBs with the expression of TH-regulated genes is congener-specific and that both hyperthyroidism- and hypothyroidism-related effects occur.
ISSN: 0077-8923
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Animal Physiology and Neurobiology Section - miscellaneous
× corresponding author
# (joint) last author

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