Title: Isolation, identification and localization of a second beetle antidiuretic peptide
Authors: Eigenheer, RA
Wiehart, UM
Nicolson, SW
Schoofs, Liliane
Schegg, KM
Hull, JJ
Schooley, DA # ×
Issue Date: Jan-2003
Publisher: Elsevier
Series Title: Peptides vol:24 issue:1 pages:27-34
Abstract: We isolated from head extracts of Tenebrio molitor a peptide that inhibits fluid secretion by the Malpighian tubules of this insect. This second antidiuretic factor, ADFb, like the previously published ADFa, works through cyclic GMP as a second messenger. It has primary structure Tyr-Asp-Asp-Gly-Ser-Tyr-Lys-Pro-His-Ile-Tyr-Gly-Phe-OH with an EC50 of approximately 240 pM in a fluid secretion assay. This peptide is now the second sequenced endogenous insect ADF which inhibits Malpighian tubule fluid secretion. Immunohistochemical techniques show that the peptide is localized in the brain; it appears to be produced mainly in two pairs of bilaterally symmetrical cells in the protocerebrum. (C) 2002 Elsevier Science Inc. All rights reserved.
ISSN: 0196-9781
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Animal Physiology and Neurobiology Section - miscellaneous
× corresponding author
# (joint) last author

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