Title: Presence of angiotensin converting enzyme (ACE) interactive factors in ovaries of the grey fleshfly Neobellieria bullata
Authors: Vandingenen, Anick
Hens, Korneel
Macours, Nathalie
Schoofs, Liliane
De Loof, Arnold
Huybrechts, Roger # ×
Issue Date: May-2002
Publisher: Elsevier Science
Series Title: Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology vol:132 issue:1 pages:27-35
Abstract: Angiotensin converting enzyme (ACE) activity, defined as a captopril-inhibitable dipeptidyl carboxypeptidase activity towards H-3-hippurylglycylglycine, was demonstrated in haemolymph, testes and ovaries of the grey fleshfly Neobellieria bullata, hereby suggesting a physiological role for ACE in these particular tissues. While the ACE activity in haemolymph and testes reached relatively high levels, only minute ACE activity could be detected in ovaries throughout the entire vitellogenic cycle. Ovarian extracts of Neobellieria bullata do contain, however, in addition to Neb-TMOF, the Neobellieria bullata trypsin modulating oostatic factor which is an in vitro and a putative in vivo substrate of ACE in circulation, several other heat-stable molecules which individually function either as an ACE substrate or ACE inhibitor. Presumably these ACE interactive factors mask ACE activity in the fly ovaries, as measured by a classic substrate-binding assay. Purification and characterisation of these ACE substrate s/inhibitors is in progress and is likely to facilitate the elucidation of the enigmatic physiological relevance of ACE in insects. (C) 2002 Elsevier Science Inc. All rights reserved.
ISSN: 1096-4959
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Animal Physiology and Neurobiology Section - miscellaneous
Department of Biology - miscellaneous
× corresponding author
# (joint) last author

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