Title: Distribution of the AMPA2 glutamate receptor subunit in adult cat visual cortex
Authors: Van Damme, Katrien ×
Massie, Ann
Vandesande, Frans
Arckens, Lut #
Issue Date: Jan-2003
Publisher: Elsevier science bv
Series Title: Brain Research vol:960 issue:1-2 pages:1-8
Abstract: In this study, we revealed the distribution of the AMPA2 glutamate receptor subunit (AMPA2) in the visual cortical areas 17 and 18 of the adult cat by means of different techniques. In situ hybridization, with a cat-specific radioactively labeled oligonucleotide probe, showed that AMPA2 mRNA as expressed mainly in cortical layers II/III and V/VI with a lower expression in layer IV and practically no signal in layer I. Immunocytochemistry, using a polyclonal AMPA2 subunit-specific antibody, showed immunoreactivity almost exclusively in the somata and dendrites of pyramidal neurons in cortical layers II/III and V/VI. Only a very faint signal was detected in layer IV Neurons with little or no AMPA2 have AMPA receptors that are highly permeable to calcium. By determining the location of AMPA2, this study therefore provides a clear examination of the distribution of Ca2--impermeable AMPA receptors over the supra-and infragranular layers of cat visual cortex. The functional implication of the absence of AMPA2 in cortical layer IV and thus the presence of C2+-permeable AMPA receptors in this layer, is still speculative and has yet to be elucidated. (C) 2002 Elsevier Science B.V. All rights reserved.
ISSN: 0006-8993
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Animal Physiology and Neurobiology Section - miscellaneous
× corresponding author
# (joint) last author

Files in This Item:
File Description Status SizeFormat
Van Damme et al._2003_Brain Res_vol960_p1-8.pdf Published 726KbAdobe PDFView/Open Request a copy

These files are only available to some KU Leuven Association staff members


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science