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Title: Long-term exposure to environmentally relevant doses of methyl-tert-butyl ether causes significant reproductive dysfunction in the zebrafish (Danio rerio)
Authors: Moreels, D. ×
Van Cauwenberghe, K.
Debaere, B.
Rurangwa, Eugène
Vromant, Nico
Bastiaens, L.
Diels, L.
Springael, Dirk
Merckx, Roel
Ollevier, F. #
Issue Date: 2006
Publisher: Setac
Series Title: Environmental toxicology and chemistry vol:25 issue:9 pages:2388-2393
Abstract: Methyl-tert-butyl ether (MTBE), an anthropogenic chemical used as a gasoline additive, is being detected at an increasing frequency in the environment. The acute lethal concentration that kills 50% of the fish test population and the chronic effects of exposure to MTBE were investigated in the zebrafish (Danio rerio). Chronic exposure over three weeks to effective MTBE concentrations as low as 0.11 mg/L induced a significant increase in the vitellogenin concentration of male fish. The impact of a chronic, eight-week exposure at effective concentrations ranging from 0.44 to 220 mg/L had no significant effect on fecundity, fertilization, or hatch rate but highly significant impacts on sperm motility. Spermatozoa of all MTBE-exposure groups showed a significantly lower straight-line velocity and lower average path velocity compared to those of the nonexposed group. These results suggest that chronic exposure to MTBE negatively affects fish sperm motility at concentrations that are environmentally relevant and several orders of magnitude lower than concentrations inducing acute effects.
ISSN: 0730-7268
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Division Soil and Water Management
Ecology, Evolution and Biodiversity Conservation Section
Laboratory for Aquatic Ecology and Evolutionary Biology (-)
× corresponding author
# (joint) last author

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