Circulating bile acids predict outcome in critically ill patients

Horvatits, Thomas; Drolz, Andreas; Rutter, Karoline; Roedl, Kevin; Langouche, Lies; Van den Berghe, Greet; Fauler, Günter; Meyer, Brigitte; Hülsmann, Martin; Heinz, Gottfried; Trauner, Michael; Fuhrmann, Valentin

doi:10.1186/s13613-017-0272-7

Circulating bile acids predict outcome in critically ill patients

Author:

Horvatits, Thomas

Drolz, Andreas ; Rutter, Karoline ; Roedl, Kevin ; Langouche, Lies ; Van den Berghe, Greet ; Fauler, Günter ; Meyer, Brigitte ; Hülsmann, Martin ; Heinz, Gottfried ; Trauner, Michael ; Fuhrmann, Valentin

Keywords:

Science & Technology, Life Sciences & Biomedicine, Critical Care Medicine, General & Internal Medicine, Bile acids, Cholestasis, Cardiogenic shock, Septic shock, Critically ill patients, ICU, CHRONIC HEART-FAILURE, MYOCARDIAL-INFARCTION, CHOLESTATIC LIVER, CARDIOGENIC-SHOCK, ACUTE PHYSIOLOGY, CRITICAL ILLNESS, GUT MICROBIOTA, SEPSIS, SERUM, INFLAMMATION, 1103 Clinical Sciences, 1117 Public Health and Health Services, 3202 Clinical sciences

Abstract:

Jaundice and cholestatic hepatic dysfunction are frequent findings in critically ill patients associated with increased mortality. Cholestasis in critically ill patients is closely associated with stimulation of pro-inflammatory cytokines resulting in impaired bile secretion and subsequent accumulation of bile acids. Aim of this study was to evaluate the clinical role of circulating bile acids in critically ill patients.