Title: Early differences in islets from prediabetic NOD mice: combined microarray and proteomic analysis
Authors: Crèvecoeur, Inne
Gudmundsdottir, Valborg
Saurabh Vig, SAURABH
Marques Camara Sodre, Fernanda
D'Hertog, Wannes
Fierro, Ana Carolina
Van Lommel, Leentje
Gysemans, Conny
Marchal, Kathleen
Waelkens, Etienne
Schuit, Frans
Brunak, Søren
Overbergh, Lut # ×
Mathieu, Chantal #
Issue Date: Mar-2017
Publisher: Springer-Verlag Heidelberg
Series Title: Diabetologia vol:60 issue:3 pages:475-489
Article number: 10.1007/s00125-016-4191-1
Abstract: Type 1 diabetes is an endocrine disease where a long preclinical phase, characterised by immune cell infiltration in the islets of Langerhans, precedes elevated blood glucose levels and disease onset. Although several studies have investigated the role of the immune system in this process of insulitis, the importance of the beta cells themselves in the initiation of type 1 diabetes is less well understood. The aim of this study was to investigate intrinsic differences present in the islets from diabetes-prone NOD mice before the onset of insulitis.
ISSN: 0012-186X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Protein Phosphorylation and Proteomics
Centre of Microbial and Plant Genetics
Gene Expression Unit
Clinical and Experimental Endocrinology
× corresponding author
# (joint) last author

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