Author:

Keywords:

Science & Technology, Life Sciences & Biomedicine, Physical Sciences, Chemistry, Medicinal, Chemistry, Organic, Pharmacology & Pharmacy, Chemistry, REVERSE-TRANSCRIPTASE, IMMUNODEFICIENCY, 0304 Medicinal and Biomolecular Chemistry, 0305 Organic Chemistry, 1115 Pharmacology and Pharmaceutical Sciences, Medicinal & Biomolecular Chemistry, 3404 Medicinal and biomolecular chemistry, 3405 Organic chemistry

Abstract:

This paper describes the design and synthesis of lipophilic bioisosteres of nucleoside triphosphates as potential inhibitors of HIV reverse transcriptase. The bioisostere is designed to mimic the conformation of the nucleoside triphosphate when complexed to a metal ion such as magnesium.