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Title: Investigation of sorbic acid volatile degradation products in pharmaceutical formulations using static headspace gas chromatography
Authors: Yarramraju, Sitaramaraju
Akurathi, Vamsidhar
Wolfs, Kris
Van Schepdael, Ann
Hoogmartens, Jos
Adams, Erwin # ×
Issue Date: 18-Jun-2007
Series Title: Journal of pharmaceutical and biomedical analysis vol:44 issue:2 pages:456-63
Abstract: An analytical method that allows simultaneous analysis of sorbic acid and its degradation products was developed using static headspace gas chromatography (HS-GC). AT-Aquawax-DA, the capillary column used, showed good selectivity and separation towards sorbic acid and its degradation products. Sorbic acid degradation was investigated in both acidic and aqueous media at room and elevated temperatures. In total 12 sorbic acid degradation products were found, 8 of which could be characterized. The method was investigated for its accuracy towards estimation of degradation products. Using the HS-GC method different batches of pharmaceutical preparations such as cold cream, cetomacrogol cream and vaseline were investigated for sorbic acid degradation products which were estimated by applying the standard addition method. Acetaldehyde was found to be the major degradation product. The other identified degradation products were: acetone; 2-methylfuran; crotonaldehyde; alfa-angelicalactone; 2-acetyl, 5-methylfuran; toluene and 2,5-dimethylfuran. Both mass spectrometeric (MS) and flame ionization detection (FID) were used. The qualitative investigation was done on HS-GC-MS and the quantitative work on HS-GC-FID.
URI: 
ISSN: 0731-7085
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pharmaceutical Analysis
× corresponding author
# (joint) last author

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