Title: Analysis of underivatized gentamicin by capillary electrophoresis with UV detection
Authors: Curiel, Harold ×
Vanderaerden, W
Velez, Herman
Hoogmartens, Jos
Van Schepdael, Ann #
Issue Date: 18-Apr-2007
Series Title: Journal of pharmaceutical and biomedical analysis vol:44 issue:1 pages:49-56
Abstract: A selective and rapid capillary zone electrophoresis method for determination of the multicomponent aminoglycoside antibiotic gentamicin is described. Baseline separation of gentamicin C1, C1a, C2, C2a and C2b components was achieved with a background electrolyte containing 0.35 mM cetyl trimethylammonium bromide, 3% methanol and 90 mM sodium pyrophosphate (pH 7.4) and detected directly with UV detection without derivatization. Quantitative analysis was performed and illustrated the potential use of capillary electrophoresis for the identification and quantitation of gentamicin components, but the application of this method is limited to a gentamicin concentration range of 2-6 mg/ml.
ISSN: 0731-7085
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pharmaceutical Analysis
× corresponding author
# (joint) last author

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