Title: The synthesis of nucleoside 5'-O-(1,1-dithiotriphosphates)
Authors: Okruszek, A ×
Olesiak, M
Balzarini, Jan #
Issue Date: 19-Dec-1994
Series Title: Journal of Medicinal Chemistry vol:37 issue:22 pages:3850-4
Abstract: Appropriately protected nucleoside 5'-O-(2-thio-1,3,2-dithiaphospholanes) react with inorganic pyrophosphate in the presence of a strong base catalyst (DBU) to give nucleoside 5'-O-(1,1-dithiotriphosphates) 1a-g. The latter compounds, including an AZT analogue, show modest antivirial activity against HIV-1 and HIV-2 replication in CEM cells. The AZT and deoxyadenosine derivatives were found to be inhibitors of HIV reverse transcriptase.
ISSN: 0022-2623
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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