ITEM METADATA RECORD
Title: Drug targeting: anti-HSV-1 activity of mannosylated polymer-bound 9-(2-phosphonylmethoxyethyl)adenine
Authors: Midoux, P ×
Negre, E
Roche, A C
Mayer, R
Monsigny, M
Balzarini, Jan
De Clercq, Erik
Mayer, E
Ghaffar, A
Gangemi, J D #
Issue Date: 18-May-1990
Series Title: Biochemical and Biophysical Research Communications vol:167 issue:3 pages:1044-9
Abstract: The antiviral drug, 9-(2-phosphonylmethoxyethyl) adenine (PMEA) was linked to a synthetic and neutral polymer bearing mannosyl residues to allow its internalization by macrophages via membrane lectins. PMEA bound to the mannosylated polymer was more efficient in vitro than free PMEA in preventing lysis of human macrophages by herpes virus.
URI: 
ISSN: 0006-291X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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