Title: Synthesis and antiviral and cytostatic activities of carbocyclic nucleosides incorporating a modified cyclobutane ring. Part 1: Guanosine analogues
Authors: Figueira, M J ×
Blanco, J M
Caamaño, O
Fernández, F
García-Mera, X
López, C
Andrei, Graciela
Snoeck, Robert
Padalko, E
Neyts, Johan
Balzarini, Jan
De Clercq, Erik #
Issue Date: Oct-1999
Series Title: Archiv der Pharmazie vol:332 issue:10 pages:348-52
Abstract: Five new carbocyclic nucleosides were prepared by constructing a guanine (compounds 3, 5) or 8-azaguanine (compounds 4, 6, and 7) base on the amino group of (1'S,3'R)-3-(3'-amino-2',2'-dimethylcyclobutyl)propan-1-ol (8), and their activities against a variety of viruses and tumor cell lines were determined. Only compounds 3 and 7 showed a detectable activity at subtoxic concentrations against some viruses tested.
ISSN: 0365-6233
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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