ITEM METADATA RECORD
Title: Synthesis and biological evaluation of an (123)I-labeled bicyclic nucleoside analogue (BCNA) as potential SPECT tracer for VZV-tk reporter gene imaging
Authors: Chitneni, Satish Kumar
Deroose, Christophe
Fonge, Humphrey
Gijsbers, Rik
Dyubankova, Natalia
Balzarini, Jan
Debyser, Zeger
Mortelmans, Luc
Verbruggen, Alfons
Bormans, Guy # ×
Issue Date: Jun-2007
Publisher: Pergamon Press
Series Title: Bioorganic & Medicinal Chemistry Letters vol:17 issue:12 pages:3458-3462
Abstract: An iodine-123 labeled bicyclic nucleoside analogue ([(123)I]-4) has been synthesized and evaluated as a potential single photon emission tomography (SPECT) reporter probe for the non-invasive imaging of expression of the varicella zoster virus thymidine kinase (VZV-tk) reporter gene. In vitro enzymatic assays revealed that the non-radioactive mono-iodo derivative 4 has good affinity for VZV-TK (IC(50): 4.2muM). Biodistribution of [(123)I]-4 was examined in normal mice. Evaluation of [(123)I]-4 in HEK-293T cells showed 1.74-fold higher accumulation in VZV-TK-expressing cells compared to control cells.
URI: 
ISSN: 0960-894X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
Medicinal Chemistry
Radiopharmacy
Molecular Virology and Gene Therapy
Nuclear Medicine & Molecular Imaging
× corresponding author
# (joint) last author

Files in This Item:
File Description Status SizeFormat
Synthesis and biological (2007).pdf Published 188KbAdobe PDFView/Open

These files are only available to some KU Leuven staff members

 


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science