Title: Syntheses and anti-HIV activities of (+/-)-norcarbovir and (+/-)-norabacavir
Authors: Huang, Weiqiang ×
Miller, Marvin J
De Clercq, Erik
Balzarini, Jan #
Issue Date: 4-Apr-2007
Publisher: Royal Society of Chemistry
Series Title: Organic & Biomolecular Chemistry vol:5 issue:8 pages:1164-1166
Abstract: Norcarbovir (1) and norabacavir (2), the desmethylene derivatives of anti-HIV agents carbovir and abacavir, were efficiently synthesized from a common intermediate . Their antitumor and antiviral activities were evaluated and the results indicate norabacavir showed comparable anti-HIV activity to that of abacavir.
ISSN: 1477-0520
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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