Title: Synthesis and anti-HIV-1 activity evaluation of 5-alkyl-2-alkylthio-6-(arylcarbonyl or alpha-cyanoarylmethyl)-3,4-dihydropyrimidin-4(3H)-ones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors
Authors: Ji, Lei ×
Chen, Fen-Er
De Clercq, Erik
Balzarini, Jan
Pannecouque, Christophe #
Issue Date: Apr-2007
Series Title: Journal of Medicinal Chemistry vol:50 issue:8 pages:1778-1786
Abstract: A series of novel S-DABO analogues (S-DABOs, 1) were synthesized and evaluated as inhibitors of human immunodeficiency virus type-1 (HIV-1). Key structural modifications included replacement of the 6-arylmethyl group by a 6-arylcarbonyl or 6-(alpha-cyanoarylmethyl) group. Most of the compounds showed only micromolar potency against HIV-1 in MT-4 cells in vitro, though two of them (3e and 3g) were unusually potent (IC50=0.09 and 0.002 microM, respectively) and selective (SI=1500 and 4600, respectively). Structure-activity relationships among the newly synthesized S-DABOs are discussed.
ISSN: 0022-2623
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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