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Title: "Lock-in" modified cyclosal nucleotides--the second generation of cyclosal prodrugs
Authors: Vukadinović, D ×
Böge, N P H
Balzarini, Jan
Meier, C #
Issue Date: 28-Oct-2005
Host Document: Nucleosides, nucleotides & nucleic acids vol:24 issue:5-7 pages:939-42
Conference: XVIth International Round Table on "Nucleosides, Nucleotides and Nucleic Acids" location:Minneapolis, Minnesota, USA date:12-16-September 2004
Abstract: A new generation of cycloSal-pronucleotides is presented. CycloSal-d4TMPs have been modified by introduction of an esterase-cleavable site in order to trap them inside cells. Hydrolysis studies in different media (PBS, CEM/0- and liver extracts) and anti-HIV evaluation of separated diastereomers revealed unexpected differences between the isomers.
ISSN: 1525-7770
Publication status: published
KU Leuven publication type: IC
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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