Author:

Keywords:

Acetylcholinesterase, Animals, Cholinesterase Inhibitors, Electrophorus, Humans, Models, Molecular, Molecular Structure, Nucleotides, 0601 Biochemistry and Cell Biology, Organic Chemistry

Abstract:

An acetylcholinesterase (AChE) assay based on the Rappaport method was established to investigate the behaviour of several cycloSal nucleotides against AChE from electrophorus electricus and human sources (purified enzymes). AChE is a physiologically essential enzyme as it catalyzes the hydrolysis of the neurotransmitter acetylcholine. No inhibition was observed in any of the cases.