Title: Towards new thymidine phosphorylase/PD-ECGF inhibitors based on the transition state of the enzyme reaction
Authors: Priego, E M ×
Mendieta, J
Gago, F
Balzarini, Jan
De Clercq, Erik
Camarasa, M J
Pérez-Pérez, M J #
Issue Date: 28-Oct-2003
Publisher: Marcel Dekker
Series Title: Nucleosides, Nucleotides & Nucleic Acids vol:22 issue:5-8 pages:951-953
Conference: XV International Round Table on "Nucleosides, Nucleotides and Their Biological Applications" location:Leuven, Belgium date:10-14 September 2002
Abstract: Computational studies have been conducted to built a closed form of TPase and to characterize the transition state of the phosphorylisis reaction catalyzed by TPase. The results obtained point to a crucial role of His-85 and the O2 of thymine in the catalysis. This modelled transition state forms the basis for the design of new TPase inhibitors.
ISSN: 1525-7770
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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