Title: Novel nucleotide analogues as potential substrates for TMPK, a key enzyme in the metabolism of AZT
Authors: Müller, H C ×
Meier, C
Balzarini, Jan
Reinstein, J #
Issue Date: 28-Oct-2003
Host Document: Nucleosides, nucleotides & nucleic acids vol:22 issue:5-8 pages:821-3
Conference: XI International Round Table on "Nucleosides, Nucleotides and Their Biological Applications" location:Leuven, Belgium date:10-14 September 2002
Abstract: Novel cyclic and acyclic analogues of dTMP and AZTMP were synthesized from the corresponding cycloSal-phosphotriesters. This method yielded the nucleotides in good yields with a simple work-up. Investigation of the substrate properties of the modified nucleotides towards TmpK showed, that they are very poor substrates for this key enzyme in the bioactivation of AZT.
ISSN: 1525-7770
Publication status: published
KU Leuven publication type: IC
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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