Title: Identification of a novel family of nucleosides that specifically inhibit HIV-1 reverse transcriptase
Authors: Chamorro, C ×
Lobatón, E
Bonache, M C
De Clercq, Erik
Balzarini, Jan
Velázquez, S
San-Félix, A
Camarasa, M J #
Issue Date: Dec-2001
Publisher: Pergamon Press
Series Title: Bioorganic & Medicinal Chemistry Letters vol:11 issue:23 pages:3085-3088
Abstract: N-3-Benzyloxycarbonylmethyl- and N-3-carboxymethyl-TBDMS-substituted nucleosides were synthesized and evaluated for activity against HIV replication. It was found that the N-3-carboxymethyl-TBDMS-substituted nucleosides were specific inhibitors of HIV-1 replication. They should be considered as members of a novel and original class of NNRTIs.
ISSN: 0960-894X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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