Title: Novel carbocyclic nucleosides containing a cyclobutyl ring: adenosine analogues
Authors: Hergueta, A R ×
Fernandez, F
López, C
Balzarini, Jan
De Clercq, Erik #
Issue Date: Sep-2001
Publisher: Pharmaceutical Society of Japan
Series Title: Chemical & Pharmaceutical Bulletin vol:49 issue:9 pages:1174-1177
Abstract: (1S,1'R)-cis-1-(3'-aminomethyl-2',2'-dimethylcyclobutyl)ethanol (1) and (1S,1'R)-cis-1-[3'-(2-aminoethyl)-2',2'-dimethylcyclobutyl]ethanol (2) were used as precursors in the synthesis of cyclobutyl nucleoside analogues containing adenine and 8-azaadenine moieties, which were tested as antiviral and antitumoral agents in a variety of assay systems. Compounds 8 and 9 displayed significant activity against respiratory syncytial virus, and compounds 14 and 15 were moderately active against vaccinia virus.
ISSN: 0009-2363
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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