Title: Design, synthesis and enzymatic activity of highly selective human mitochondrial thymidine kinase inhibitors
Authors: Manfredini, S ×
Baraldi, P G
Durini, E
Porcu, L
Angusti, A
Vertuani, S
Solaroli, N
De Clercq, Erik
Karlsson, A
Balzarini, Jan #
Issue Date: 27-Jun-2001
Series Title: Bioorganic & medicinal chemistry letters vol:11 issue:10 pages:1329-32
Abstract: Highly selective arabinofuranosyl nucleosides, which inhibit the mitochondrial thymidine kinase (TK-2) without affecting the closely related herpes simplex virus type 1 thymidine kinase (HSV-1 TK), varicella-zoster virus thymidine kinase (VZV-TK), cytosolic thymidine kinase (TK-1) or the multifunctional Drosophila melanogaster deoxyribonucleoside kinase (Dm-dNK), have been obtained. SAR studies indicate a close relation between the length of the substituent at the 2' position of the arabinofuranosyl moiety and the inhibitory activity.
ISSN: 0960-894X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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