Title: Cytotoxic 2,6-bis(arylidene)cyclohexanones and related compounds
Authors: Dimmock, J R ×
Kumar, P
Nazarali, A J
Motaganahalli, N L
Kowalchuk, T P
Beazely, M A
Wilson Quail, J
Oloo, E O
Allen, T M
Szydlowski, J
DeClercq, E
Balzarini, Jan #
Issue Date: Nov-2000
Series Title: European journal of medicinal chemistry vol:35 issue:11 pages:967-977
Abstract: A number of 2-arylidenecyclohexanones 1, 2, 6-bis(arylidene)cyclohexanones 2 and related Mannich bases 3-5 were prepared. Various torsion angles as well as atomic charges on olefinic carbon atoms were determined by molecular modelling on all compounds. These molecules showed cytotoxicity towards murine P388 and L1210 cells as well as to human Molt 4/C8 and CEM T-lymphocytes. The average cytotoxicity of the dienones 2 was more than three times greater than was found with the monoarylidene analogues 1, and, in general, were slightly more cytotoxic than the Mannich bases 3-5. A number of the compounds displayed potency towards a panel of human tumour cell lines and most of the representative compounds in series 2-5 were selectively toxic to colon cancers and leukaemic cells.
ISSN: 0223-5234
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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