Title: Highly stereoselective synthesis and biological properties of nucleoside analogues bearing a spiro inserted oxirane ring
Authors: Tronchet, J M ×
Kovacs, I
Seman, M
Dilda, P
De Clercq, Erik
Balzarini, Jan #
Issue Date: 27-Nov-2000
Series Title: Nucleosides, nucleotides & nucleic acids vol:19 issue:4 pages:775-94
Abstract: Starting from 2',5'-di-O-TBDMS-3'-ketouridine 1 or its thymine analogue 2, both xylo (3-10) and ribo (20) epimers of a series of 3"-substituted 3'-spironucleosides have been obtained in good yields and with a total stereoselectivity. Most new compounds were moderately cytotoxic with in some cases slightly selective antiproliferative activities. None of these compounds was active against HIV, but some other antiviral activities against HSV-2, CMV, EBV, or VZV, in the micromolar range, were noted in specific cases.
ISSN: 1525-7770
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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