Title: Synthesis and antiviral and antineoplastic activities of some novel carbocyclic guanosine analogues with a cyclobutane ring
Authors: Blanco, J M ×
Caamaño, O
Fernández, F
García-Mera, X
Hergueta, A R
López, C
Rodríguez-borges, J E
Balzarini, Jan
De Clercq, Erik #
Issue Date: 26-Dec-1999
Series Title: Chemical & pharmaceutical bulletin vol:47 issue:9 pages:1314-7
Abstract: Cyclobutyl nucleoside analogues containing guanine and 8-azaguanine (compounds 5-10) were prepared from (1R,cis)-3-aminomethyl-2,2-dimethylcyclobutylmethanol (1). All were evaluated as antiviral and antitumoral agents in a variety of assay systems. Compounds 6 and 7 showed a noteworthy activity against a respiratory syncytial virus and compound 10 was moderately active against vaccinia virus. Only compound 5 showed some cytostatic activity.
ISSN: 0009-2363
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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