Title: Simple mono-derivatisation of the aryl moiety of D4A and DDA-based phosphoramidate prodrugs significantly enhances their anti-HIV potency in cell culture
Authors: Siddiqui, A Q ×
McGuigan, C
Ballatore, C
Wedgwood, O
De Clercq, Erik
Balzarini, Jan #
Issue Date: 26-Oct-1999
Series Title: Bioorganic & medicinal chemistry letters vol:9 issue:17 pages:2555-60
Abstract: Simple mono-derivatisation of the aryl moiety of some phosphoramidate pronucleotide derivatives of d4A and ddA served to increase the lipophilicity of these membrane-soluble prodrugs. A concomitant and significant enhancement of potency against HIV-1 and HIV-2 in vitro was observed for the ddA- and d4A-based prodrugs compared to the original underivatised prodrugs.
ISSN: 0960-894X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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